18/09/2019
The Human Resources Strategy for Researchers

H/F Doctoral position at IPBS, Toulouse on Osteoclast

This job offer has expired


  • ORGANISATION/COMPANY
    CNRS
  • RESEARCH FIELD
    Biological sciencesBiology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    08/10/2019 23:59 - Europe/Brussels
  • LOCATION
    France › TOULOUSE
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    35
  • OFFER STARTING DATE
    02/12/2019

Applicants should be trained in cell biology. Experiences in biophysics would be a plus. The position is open for at three years. The application dead line is October, 15th, for a position to be opened in December 2019 (for 3 years). Applicants should submit a presentation letter, a curriculum vitae including a full list of publications and at least two references to verollet-poincloux@ipbs.fr.

Team: Differentiation and Activation of Phagocytes
https://phagocytes.weebly.com/
Group leader: I. Maridonneau-Parini
PhD supervisor: C. Vérollet, christel-verollet
Institute of Pharmacology and Structural Biology
CNRS UMR 5089, Toulouse, France

The Institute of Pharmacology and Structural Biology (www.ipbs.fr) in Toulouse, FRANCE has an open doctoral position to study the formation of human osteoclasts. The skeleton is subjected to continuous remodeling, which mainly relies on the concerted and balanced action of bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoclasts are multinucleated myeloid cells that differentiate from myeloid precursor. With age and in various pathological conditions, including HIV-1 infection (1), osteoclast activity takes over that of osteoblasts. This leads to a progressive reduction of bone mass, i.e. osteoporosis. In a context where the number of people suffering from osteoporosis is dramatically increasing worldwide, in particular due to general population aging, there is a need to better characterize, at the fundamental level, the mechanisms of osteoclast formation and the impact of age on this process. In this project, we want to decipher the mechanisms of cell-to-cell fusion leading to the formation of human osteoclasts. Thanks to a collaboration with LAAS/CNRS (Toulouse), a microfluidic cell-pairing approach will be developed to facilitate the formation and the quantification of cell-to-cell fusion processes. First, we will study the dynamics of the fusion of osteoclast precursors and the molecular actors of this phenomenon, focusing in particular on the actin cytoskeleton on the adhesion machinery. Second, we will investigate how age affects the efficiency and regulation of osteoclast fusion. This project is a continuation of our work on osteoclast and cell-to-cell fusion processes, and will benefit on our expertise on the regulation of macrophage functions (see references).

Required Research Experiences

  • RESEARCH FIELD
    Biological sciences
  • YEARS OF RESEARCH EXPERIENCE
    None
  • RESEARCH FIELD
    Biological sciencesBiology
  • YEARS OF RESEARCH EXPERIENCE
    None

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Biological sciences: Master Degree or equivalent
  • REQUIRED LANGUAGES
    FRENCH: Basic
Work location(s)
1 position(s) available at
INSTITUT de PHARMACOLOGIE et de BIOLOGIE STRUCTURALE
France
TOULOUSE

EURAXESS offer ID: 446629
Posting organisation offer ID: 11842

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